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Oral health • Saliva based

Perio

Perio Saliva Test

Non-invasive saliva testing that identifies key periodontal pathogens before they drive irreversible tissue destruction—so clinicians can personalize therapy and monitor response over time.

For dental + medical practices CLIA laboratory workflow

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Benefits*

Detects high-risk periodontal pathogens from a simple saliva sample.
Supports precision-guided therapy planning instead of guess-and-check treatment.
Helps communicate risk to patients with visual, easy-to-understand reporting.
Enables ongoing monitoring to track response and motivate maintenance visits.

View sample Perio report

The complete periodontal risk profile in just one test.

Perio consolidates key red-complex and orange-complex organisms into a single, CLIA-validated saliva assay. Use it to move beyond probing depth and bleeding scores to a more complete understanding of microbial load.

Reports classify risk tiers, provide organism-level detail, and tie findings to evidence-based therapy recommendations—helping align providers, hygienists, and patients around a clear plan of action.

View Clinical Evidence

Baseline

Identify high-risk periodontal pathogens

Quantitative organism data supports diagnosis and guides initial therapy selection.

4–6 weeks

Measure response to treatment

Repeat testing shows shifts in microbial burden and helps refine adjunctive therapy.

Maintenance

Monitor long-term stability

Periodic re-testing helps catch relapse early and supports proactive maintenance scheduling.

Perio panel design

A pathogen panel built for real-world periodontal care.

The Perio assay was designed with practicing clinicians to capture organisms most associated with attachment loss, deep pocketing, and refractory disease—without over-complicating chairside decisions.

Clinically relevant organisms

Includes key red-complex and orange-complex species linked to moderate–severe periodontitis.

Actionable reporting

Risk tiering and organism call-outs mapped to therapy considerations you can actually use.

Simple saliva collection

Non-invasive swish-and-spit workflow that fits seamlessly into hygiene visits.

Clear patient visuals

Color-coded report visuals help patients see why treatment and follow-up matter.

Systemic disease risks connected to oral pathogens.

Perio helps uncover pathogen patterns that have been associated in the literature with systemic conditions. Use these insights to start conversations about whole-body health, coordinate care, and motivate behavior change.

Condition

Oral pathogens detected

Clinical implication

Alzheimer’s disease

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Chronic oral infection and inflammation have been linked to neurodegenerative risk in emerging research.

Heart disease / attack

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Elevated pathogen burden has been associated with atherosclerosis, endothelial injury, and cardiovascular events.

Stroke

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Periodontal organisms have been detected in atheromatous plaques and linked to cerebrovascular events.

Diabetes

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Bi-directional links exist between periodontal inflammation and glycemic control.

Cancer

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Certain oral pathogens have been associated with elevated risk for gastrointestinal and other cancers.

Adverse pregnancy outcomes

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Periodontal infections have been linked to preterm birth, low birth weight, and other pregnancy complications.

High blood pressure

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Associations have been described between periodontal disease, systemic inflammation, and hypertension.

Women’s health & gut health

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Oral pathogens contribute to systemic inflammatory load that can impact hormonal balance and gut ecology.

Clinical perspective

The Perio difference in whole-body dentistry.

Perio helps connect what you see in the mouth with what may be happening systemically. Use saliva-based pathogen data to support conversations with patients, hygienists, and medical colleagues about risk, prevention, and long-term health.

Video: Learn how Perio saliva testing fits into a modern perio and whole-body health protocol.

Root-cause periodontal insights

Move beyond “pockets and bleeding” to organism-level data that explains why some patients fail to respond to standard care.

Whole-body risk conversations

Use Perio results alongside systemic risk charts to connect oral pathogens to cardiovascular, metabolic, and pregnancy outcomes.

Practice-ready workflow

Swish-and-spit collection, clear labeling, and CLIA lab processing slot directly into hygiene visits and recall appointments.

Clinical and business support

Implementation guides, scripting, and SimplyTest support help your team launch Perio with confidence and measure impact over time.

Complete your oral health protocol with Perio.

Pair Perio saliva testing with your existing periodontal program to close the loop between clinical findings, microbial data, and patient behavior. Use results to personalize maintenance intervals, adjunctive therapies, and communication—so patients understand exactly why their care plan matters.

Talk with our team

Make periodontal risk visible at a glance.

The Perio sample report turns organism data into simple visuals patients and providers can read in seconds.

Use the report chairside to explain current status, set expectations for therapy, and track improvement over time with repeat testing.

Reports can be downloaded to your practice management or EHR system for documentation.